[Wolfgang Schmidt] Regulation of riboflavin biosynthesis in Medicago truncatula rootsPOST:
In some species including Medicago truncatula, iron deficiency results in accumulation of riboflavin, a response that improve the acquisition of iron from recalcitrant pools. A study conducted in collaboration with the group of Wen Hao Zhang (State Key Laboratory of Vegetation and Environmental Change, LVEC) showed that the protein kinase CIPK12 regulates ferric reduction by accumulation of riboflavin and its derivatives. The Calcineurin B-like proteins CBL3 and CBL8 interact with CIPK12, which negatively regulates the expression of genes encoding key enzymes in the riboflavin biosynthesis pathway. The findings uncover a new regulatory mechanism in which CIPK12 regulates riboflavin biosynthesis and iron-deficiency responses in plants.