[Ming-Hsiun Hsieh] TH2 is involved in vitamin B1 biosynthesis and homeostasis
POST:
Fig. 1 THIAMIN REQUIRING2 (TH2) is involved in thiamin diphosphate biosynthesis and homeostasis. (A) The Arabidopsis th2-3 mutant is pale green. (B) A proposed vitamin B1 biosynthesis pathway in Arabidopsis. The TMP/TDP phosphatase activity of TH2 connects TMP, thiamin, and TDP into a me
Dr. Ming-Hsiun Hsieh’s laboratory reports that THIAMIN REQUIRING2 (TH2) encodes a thiamin monophosphate (TMP)/thiamin diphosphate (TDP) phosphatase localized to the cytosol, mitochondrion, and nucleus in Arabidopsis. The TMP/TDP phosphatase activity of TH2 connects TMP, thiamin, and TDP into a metabolic cycle involved in TDP biosynthesis and homeostasis (Fig. 1). The paper is published in The Plant Journal (http://doi.org/10.1111/tpj.15895). The contributing authors include Wei-Yu Hsieh, Hsin-Mei Wang, Yi-Hsin Chung, Kim-Teng Lee, and Hong-Sheng Liao from Dr. Hsieh’s lab.