[Wolfgang Schmidt] An interactome of histone deacetylase HDA19

HISTONE DEACETYLASE 19 (HDA19) belongs to class 1 of the Reduced Potassium Dependence3/Histone Deacetylase-1 (RPD3/HDA1) superfamily and is possibly the most intensively studied HDA. Similar to other RPD3-type HDACs, HDA19 forms distinct complexes that play pivotal roles in various stress responses, some of which possess yet unexplored stress-specific compositions. In a recently published Data Report, Isabel Vélez-Bermúdez from Wolfgang Schmidt’s group provides an immunoprecipitation (IP)-based analysis of the HDA19 interactome in etiolated Arabidopsis seedlings. The dataset identified a large suite of putative novel interacting partners of HDA19, constituting a valuable resource for follow-up research on novel interacting partners of this central protein. Besides the usual suspects (aka expected binding partners), the authors show that HDA19 interacts with proteins involved in chromatin remodelling, nuclear protein export/import, protein ubiquitination associated with DNA damage repair, and chloroplast-nucleus signalling, suggesting a wide range of largely unexplored functions of HDA19 in etiolated Arabidopsis seedlings.

Link: https://www.frontiersin.org/articles/10.3389/fpls.2023.1296767/full