[Chih-Hang Wu] Review:NLR immune receptors in plants and animals

Intracellular NLR-type receptors play important roles in the immune systems of both plants and animals. They can detect the proteins secreted from the invading pathogens and activate immune responses. Animal NLRs form “inflammasome” complexes upon pathogen detection, and recent studies indicated that plant NLRs form similar complexes named “resistosomes”. Assistant Research Fellow Chih-Hang Wu wrote this review together with Pingtao Ding (The Sainsbury Laboratory, UK; currently Assistant Professor at University of Leiden, Netherlands), and Zane Duxbury (Syngenta, UK) to summarize and compare the latest finding on the biochemistry and biophysics of plant and animal NLR proteins. This article was published in 2021 in the Annual Review of Plant Biology:  https://www.annualreviews.org/doi/abs/10.1146/annurev-arplant-080620-104948