About Us

We are a research group in the Institute of Plant and Microbial Biology, Academia Sinica, Taiwan. The principal investigator of our group is Chih-Horng Kuo. Our research interests include: Evolution, Genomics, Transcriptomics, Bioinformatics, Taxonomy, and Microbiology.


本研究室隸屬於中央研究院植物暨微生物學研究所, 研究室主持人為郭志鴻。 我們的研究興趣包含了演化生物學, 基因體學, 轉錄體學, 生物資訊學, 分類學, 以及微生物學

Research: Evolutionary and Functional Genomics of Symbiotic Bacteria

In microbial evolution, the development of a host-dependent lifestyle often has profound effects on the genome organization. To better understand the evolutionary processes and functional consequences associated with these genetic changes, we utilize genomics, transcriptomics, and molecular genetics approaches to conduct comparative analyses among bacteria with different ecological niches or phenotypes. The recent research projects in our lab are based on two main study systems:

(1) Mollicutes

The class Mollicutes contains diverse groups of host-associated bacteria with no cell wall, including Mycoplasma (many are vertebrate pathogens), 'Candidatus Phytoplasma' (plant pathogens), and Spiroplasma (mostly insect symbionts, some are plant pathogens). Our short-term goal in this system is to investigate the genetic mechanisms that may explain the differences among species or strains with distinct phenotypes. In the long-term, we plan to generate sufficient genomic data to allow for comprehensive comparisons that improve our understanding of these bacteria.

(2) Agrobacterium

The plant-associated bacteria in the genus Agrobacterium are important because of their biotechnological use in plant transformation and their phytopathogenicity that impacts agriculture. Through collaboration with Dr. Erh-Min Lai in our institute and others, we are interested in the genetic diversity, genome evolution, and functional characterization across different subgroups within this diverse genus.



(1) 柔膜菌綱 (Mollicutes)

柔膜菌綱為一群不具有細胞壁之宿主依存性細菌,包括黴漿菌(Mycoplasma; 含多種脊椎動物病原)、植物菌質體 ('Candidatus Phytoplasma'; 植物病原)、及螺旋菌質體 (Spiroplasma; 多為昆蟲共生菌,部分物種為植物病原) 等代表性物種。本研究室的短期目標為調查可解釋物種間或菌株間表現型差異之遺傳機制,而長期目標則是累積足夠的基因體資料以進行完整的比較分析藉以了解這群細菌。

(2) 農桿菌屬 (Agrobacterium)