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賀端華 (Ho, Tuan-hua)

客座講座
中央研究院院士

  • Ph.D. Biochemistry, Michigan State University, USA
  • +886-2-2787-1079(Lab)
  • +886-2-2787-1188(Office)
  • tho@sinica.edu.tw
  • Hormone and stress signaling; function of stress proteins; lignocellulose degrading enzymes

研究領域
      本團隊的研究方向主要在嘗試回答生物學中的兩個重要問題:一、生物在生長發育過程中如何做出正確的抉擇?二、生物如何應對環境的變化? 同時,本實驗室也有興趣發展以纖維素為原料產製生質燃油所需的微生物酵素。

調控種子休眠/ 萌芽的荷爾蒙拮抗作用

促進發芽的GA與抑制發芽的ABA這兩種植物荷爾蒙之間的交互作用,調控了種子由休眠過渡到發芽的過程。因此針對此調控機制的研究,本團隊除了探討GA 、ABA個別的訊息傳導,也同時探討兩種荷爾蒙之間的交互作用。

逆境蛋白質的功能

      由於植物不能移動無法逃避逆境,植物傾向於藉由改變基因表現以應付環境的變化。然而,許多逆境誘導的蛋白質功能尚未被研究。本團隊目前研究的逆境蛋白包括HVA1(屬於LEA蛋白質)、HVA22(計畫性細胞死亡的抑制蛋白)以及一個具高量脯氨酸的醣蛋白RePRP。這些逆境蛋白質對水稻根部的發育及功能是目前研究的重點。

開發由纖維素衍生出之生質燃料(cellulosic biofuel)相關的微生物酵素

      本研究室另外致力於發現、改進及應用微生物的纖維素分解酵素在分解農業廢棄物如稻桿、甘蔗渣於生質燃料的生產。研究的酵素種類包括endo-glucanase 、exo-glucanase及β-glucosidase ,已經從台灣本土微生物及昆蟲分離並選殖到數個具有高活性且穩定的酵素。目前正進行這些蛋白質結構與其酵素功能的關係研究,以提供未來改進這些酵素的基礎。

All publication list

Selected publication list

  • Lo SF, Ho THD*, Liu YL, Jiang MJ, Hsieh KT, Chen KT, Yu LC, Lee MH, Chen CY, Huang TP, Kojima M, Sakakibara H, Chen LJ*, and Yu SM* (2016) Ectopic expression of specific GA2 oxidase mutants promotes yield and stress tolerance in rice. Plant Biotechnology Journal in press.
  • Lo SF, Fan MJ, Hsing YI, Chen LJ, Chen S, Wen IC, Liu YL, Chen KT, Jiang MJ, Lin MK, Rao MY, Yu LC, Ho THD*, and Yu SM* (2016) Genetic resources offer efficient tools for rice functional genomics research. Plant, Cell & Environment 39:998-1013.
  • Yu SM*, Lo SF, and Ho THD (2015) Source-sink communication: regulated by hormone, nutrient, and stress cross-signaling. Trends in Plant Science 20:844-57.
  • Chen YS, Lo SF, Sun PK, Tseng TH, Lu CA , Ho THD*, Yu SM* (2015) An ABA-inducible Synthetic Promoter Regulates HVA1 in Rice Leading to Root Growth, Stress Tolerance, and Efficient Nutrient Utilization. Plant Biotech J 13:105-116 (featured article for the cover of this issue).
  • Lin CR, Lee KW, Chen CY, Hong YF, Chen JL, Lu CA, Chen KT, Ho THD, and Yu SM* (2014) SnRK1A-interacting negative regulators modulate the nutrient starvation signaling sensor SnRK1 in source-sink communication in cereal seedlings under abiotic stress. Plant Cell 26(2):808-827.
  • Yoneda A, Kuo HWD, Ishihara M, Azadi P, Yu SM, and Ho THD* (2014) Glycosylation variants of a β-glucosidase secreted by a Taiwanese fungus, Chaetomella raphigera, exhibit variant-specific catalytic and biochemical properties. PLOS ONE 9(9):e106306 doi:10.1371/journal.pone.0106306.
  • Yeh YF, Chang SCY, Kuo HW, Tong CG, Yu SM, Ho THD* (2013) A metagenomic approach for the identification and cloning of an endoglucanase from rice straw compost. Gene 519:360-366.
  • Tseng IC, Hong CY, Kao YT, Yu SM, and Ho THD* (2013) A group of highly proline-rich glycoproteins mediate ABA/stress regulated root growth in rice. Plant Physiol. 163:118-134.  
  • Hong YF, Ho THD, Wu CF, Ho SL, Yeh RH, Lu CA, Chen PW, Yu LC, Yu SM* (2012) Convergent starvation signals and hormone crosstalk in regulating nutrient mobilization upon germination. Plant Cell 24:7 2857-2873.
  • Ng IS, Tsai SW, Ju YM, Yu SM*, Ho THD* (2011) Dynamic synergistic effect on Trichoderma reesei cellulases by novelβ-glucosidases from Taiwanese Fungi. Bioresource Technology 102:6073-6081.

博士後研究 Postdoctoral Fellow
黃冠穎 Kuan-Ying Huang
林婉琦 Wan-Chi Lin
蕭雪倫 An-Shan Sharon Hsiao
曾怡潔 I-Chieh Tseng

研究助理 Research Assistant
李振維 Chen-Wei Li
王清嵐 Ching-Lan Wang
李揚 Yang Lee

博士班研究生 Doctoral Student
吳玫慧 Mei-Huey Wu
吳孟璇 Meng-Hsuan Wu
高睦融 Mu-Rong Kao